San Francisco Giants vs San Diego Padres Prediction 04/29/2025 | MLB

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Without a doubt, one of the best games on Tuesday’s MLB schedule will be the one played at PETCO Park between the San Francisco Giants and the San Diego Padres, National League West division rivals who have had a great start to the season.

San Francisco Giants vs San Diego Padres: Under

The Padres’ pitchers have done a great job early in the season, and their starter is proof of that. However, the Giants are not far behind, as they have limited their opponents to 3.69 runs per game and today they will have Logan Webb on the mound, who pitched 6.1 innings without allowing a run against the Brewers in his previous outing and has a magnificent ERA of 1.44 this season. This will not be a good game for the offenses, who will leave a low-scoring result.

Injuries for San Francisco Giants:

J. Fitzgerald Day to day.

J. Encarnación Out.

Injuries for San Diego Padres:

L. Arraez Out.

B. Lockridge Out.

J. Cronenworth Out.

J. Merrill Out.

San Francisco Giants vs San Diego Padres: Padres Moneyline

Thanks to an impressive, unexpected, and rarely seen play to finish their Sunday game, the Giants managed to win a second consecutive game, in which their offense couldn’t do much for the third day in a row, but the pitching responded correctly. Those offensive problems could be well exploited by the Padres, who have the third fewest runs allowed in MLB (2.96 per game) and who will have Nick Pivetta on the mound today, who has an ERA of 1.20 after 30.0 innings pitched. This will be a very close game, but considering that the Padres will be at home, we expect them to take the win.

San Francisco Giants vs San Diego Padres Prediction

As expected, this will be a very even and hard-fought clash until the end, and considering the starters, also one with few annotations, so the details will be important and will define things. Therefore, we expect a great pitching duel in which the Padres take the win.

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The odds provided are an estimate, please check before you bet.